Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160129 | 0.91 | NR1I2 (0.50) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11468011 | 0.86 | MAPT (0.56) | LMNAMAPTTP53KDM4E | |
| SCHEMBL11158937 | 0.85 | CASR (0.57) | LMNAMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL11634049 | 0.83 | NR1I2 (0.54) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11479043 | 0.81 | NR1I2 (0.59) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11469861 | 0.79 | CASR (0.55) | LMNAMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL11635741 | 0.78 | NR1I2 (0.49) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11462895 | 0.77 | MAPT (0.44) | LMNAMAPTTP53PTGDR2 | |
| SCHEMBL11460555 | 0.76 | MAPT (0.53) | LMNAMAPTTP53 | |
| Fluquazone SCHEMBL43464 | 0.76 | MAPT (0.58) | LMNAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4202895-A | 1-Polyhaloalkyl-2(1H)-quinazolinone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-05-13 | — | — | US | disclosed |
| US-3953446-A | Process for preparing quinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-04-27 | — | — | US | disclosed |