Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11454363 | 0.88 | SIRT2 (0.46) | MEN1KMT2AALDH1A1TSHRHDAC4 | |
| SCHEMBL11446517 | 0.88 | ADRB2 (0.49) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL11454600 | 0.86 | USP2 (0.47) | MEN1KMT2AALDH1A1GAAKDM4E | |
| SCHEMBL11446599 | 0.86 | ADRA1D (0.51) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL11457400 | 0.85 | ADRA1D (0.53) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL11604589 | 0.83 | KDM4E (0.43) | ALDH1A1KDM4E | |
| SCHEMBL11447082 | 0.83 | IGF1R (0.46) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11446594 | 0.82 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL11447343 | 0.82 | ADRB2 (0.52) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL11456900 | 0.81 | SLC18A3 (0.49) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |