Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456900 | 0.87 | SLC18A3 (0.49) | — | |
| SCHEMBL11454600 | 0.85 | USP2 (0.47) | ALDH1A1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL11604589 | 0.84 | KDM4E (0.43) | ALDH1A1KDM4EPARP1 | |
| SCHEMBL11446599 | 0.82 | ADRA1D (0.51) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL11465170 | 0.82 | MEN1 (0.51) | ALDH1A1KMT2AMEN1ATMMAPT | |
| Hydrochloric Acid SCHEMBL11457400 | 0.81 | ADRA1D (0.53) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL11454363 | 0.80 | SIRT2 (0.46) | ALDH1A1KMT2AMEN1MAPTPARP2 | |
| SCHEMBL11447161 | 0.79 | ADRB2 (0.55) | ALDH1A1KDM4E | |
| SCHEMBL11446219 | 0.79 | ADRA1D (0.45) | ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL11446601 | 0.79 | HTR1A (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |