SCHEMBL114652

SCHEMBL114652

Nc1nc2c(nc(O)n2[C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PNP P00491 3/20 0.55
CYP3A4 P08684 1/20 0.45
MAPT P10636 1/20 0.45
ADRB1 P08588 1/20 0.45
DNMT1 P26358 1/20 0.45
POLB P06746 1/20 0.44
LMNA P02545 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
TK1 P04183 1/20 0.42
TP53 P04637 1/20 0.41
HTT P42858 1/20 0.41
PDE4D Q08499 1/20 0.41
PDE3A Q14432 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
ALOX12 P18054 1/20 0.40
ADRA1A P35348 1/20 0.40
TLR7 Q9NYK1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL195548 1.00 PNP (0.55) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL21779018 1.00 PNP (0.55) PNPCYP3A4MAPTADRB1DNMT1
Phosphoric Acid SCHEMBL9013988 0.96 PNP (0.52) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL655857 0.90 PNP (0.65) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL655858 0.90 PNP (0.65) PNPCYP3A4MAPTADRB1DNMT1
Citric Acid SCHEMBL3066161 0.89 PNP (0.46) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL3868526 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL13351290 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL18723297 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL14543297 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8544 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036979-A Extraction method of chicory aerial part polysaccharide, and related application and evaluation method 金木集团有限公司 2026-05-15 CN claimed
CN-122012716-A Tumor early detection method and system based on DNA features 深圳市本源生物科技有限公司 2026-05-12 CN claimed
US-12577554-B2 Methods for purification of messenger RNA TRANSLATE BIO, INC. (US) 2026-03-17 US claimed
EP-4705468-A1 MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO California Institute of Technology (US) 2026-03-11 EP claimed
US-12569572-B2 Messenger RNA therapy for the treatment of Friedreich's ataxia TRANSLATE BIO, INC. (US) 2026-03-10 US claimed
US-20260028616-A1 METHODS AND APPARATUS FOR DUPLEX NUCLEOTIDE PURIFICATION AGILENT TECHNOLOGIES, INC. (US) 2026-01-29 US claimed
EP-4677078-A1 MANUFACTURE OF MESSENGER RNA WITH KP34 POLYMERASE Sanofi Pasteur Inc. (US) 2026-01-14 EP claimed
US-12509698-B2 Synthesis and structure of high potency RNA therapeutics ARCTURUS THERAPEUTICS, INC. (US) 2025-12-30 US claimed
US-12473596-B2 Delaying real-time sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2025-11-18 US claimed
US-20250325498-A1 8-OHdG CONCENTRATION DECREASE ACCELERATOR, MALONDIALDEHYDE (MDA) CONCENTRATION DECREASE ACCELERATOR, ZIP4 CONCENTRATION INCREASE ACCELERATOR, OR SERUM ZINC CONCENTRATION INCREASE ACCELERATOR FOR JEJUNUM WATANABE OYSTER LABORATORY, CO., LTD. (JP) 2025-10-23 US claimed
WO-2003016527-A2 PROCESS FOR THE DETECTION OF OXIDATIVE STRESS AND KIT FOR ITS IMPLEMENTATION PROBIOX SA (BE) 2003-02-27 WO claimed
EP-1267162-A1 SIMPLE METHOD OF BIOLOGICALLY EVALUATING NATURAL AND ARTIFICIAL CHEMICALS BY USING DNA INJURY INDEX AND APPARATUS THEREFOR Ecological Technology Research, Ltd. (JP) 2002-12-18 EP claimed
US-5950634-A PREPARING A CHART FOR ASSESSING OXIDATIVE STRESS WHEREIN NUMERICAL FIGURE REPRESENTING THE DEGREE OF EXCESS OR DEFICIENCY OF AN INDICATOR SUBSTANCE INDICATING OXIDATIVE STRESS IN HUMANS NIKKEN FOODS CO., LTD. (JP) 1999-09-14 US claimed
EP-0767842-A1 METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING DARWIN MOLECULAR CORPORATION (US) 1997-04-16 EP claimed
WO-1996000797-A1 METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING DARWIN MOLECULAR CORP (US) 1996-01-11 WO claimed
US-5317013-A Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1994-05-31 US claimed
US-4948730-A INDUCING INTERFERON PRODUCTION SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1990-08-14 US claimed
US-4643992-A Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1987-02-17 US claimed
EP-0112632-A2 Use of 8-substituted guanine derivatives in the manufacture of a medicament. SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1984-07-04 EP claimed
WO-1984001898-A1 MODULATION OF ANIMAL CELLULAR RESPONSES WITH COMPOSITIONS CONTAINNG 8-SUBSTITUTED GUANINE DERIVATIVES SCRIPPS CLINIC RES (US) 1984-05-24 WO claimed