SCHEMBL21779018

SCHEMBL21779018

Nc1nc2c(nc(O)n2C2CC(O)C(CO)O2)c(=O)[nH]1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PNP P00491 3/20 0.55
CYP3A4 P08684 1/20 0.45
MAPT P10636 1/20 0.45
ADRB1 P08588 1/20 0.45
DNMT1 P26358 1/20 0.45
POLB P06746 1/20 0.44
LMNA P02545 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
TK1 P04183 1/20 0.42
TP53 P04637 1/20 0.41
HTT P42858 1/20 0.41
PDE4D Q08499 1/20 0.41
PDE3A Q14432 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
ALOX12 P18054 1/20 0.40
ADRA1A P35348 1/20 0.40
TLR7 Q9NYK1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL195548 1.00 PNP (0.55) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL114652 1.00 PNP (0.55) PNPCYP3A4MAPTADRB1DNMT1
Phosphoric Acid SCHEMBL9013988 0.96 PNP (0.52) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL655857 0.90 PNP (0.65) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL655858 0.90 PNP (0.65) PNPCYP3A4MAPTADRB1DNMT1
Citric Acid SCHEMBL3066161 0.89 PNP (0.46) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL3868526 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL13351290 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL18723297 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1
SCHEMBL14543297 0.88 PNP (0.54) PNPCYP3A4MAPTADRB1DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240153578-A1 METHOD OF CHARACTERISING A CANCER CAMBRIDGE ENTERPRISE LIMITED (GB) 2024-05-09 US disclosed
EP-4315339-A1 METHOD OF CHARACTERISING A CANCER Cambridge Enterprise Limited (GB) 2024-02-07 EP disclosed
US-20230375446-A1 REAGENT, KIT AND METHOD FOR STORING URINE SAMPLE HEALTHCARE SYSTEMS CO., LTD. (JP) 2023-11-23 US disclosed
EP-4276197-A2 MAPPING THE LOCATION, TYPE AND STRAND OF DAMAGED NUCLEOTIDES IN DOUBLE-STRANDED DNA New England Biolabs, Inc. (US) 2023-11-15 EP disclosed
EP-4224161-A1 REAGENT, KIT AND METHOD FOR STORING URINE SAMPLE Healthcare Systems Co. Ltd. (JP) 2023-08-09 EP disclosed
EP-3710596-B1 MAPPING THE LOCATION, TYPE AND STRAND OF DAMAGED NUCLEOTIDES IN DOUBLE-STRANDED DNA NEW ENGLAND BIOLABS INC (US) 2023-08-02 EP disclosed
US-11713484-B2 Mapping the location, type and strand of damaged and/or mismatched nucleotides in double-stranded DNA BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT 2023-08-01 US disclosed
CN-110714005-B Functional microsphere for enriching oxidized nucleic acid and method for enriching oxidized nucleic acid 青岛大学 2022-12-16 CN disclosed
WO-2022200293-A1 METHOD OF CHARACTERISING A CANCER CAMBRIDGE ENTERPRISE LIMITED (GB) 2022-09-29 WO disclosed
US-20200325533-A1 Mapping the Location, Type and Strand of Damaged and/or Mismatched Nucleotides in Double-Stranded DNA NEW ENGLAND BIOLABS, INC. (US) 2020-10-15 US disclosed
US-10577481-B2 Polymer CANON KABUSHIKI KAISHA (JP) 2020-03-03 US disclosed
CN-110714005-A Functional microsphere for enriching oxidized nucleic acid and method for enriching oxidized nucleic acid 青岛大学 2020-01-21 CN disclosed
CN-110564811-A Method for enriching oxidized nucleic acids 青岛大学 2019-12-13 CN disclosed
CN-108060206-A Application of the metabolin of Physarum Polycephalum as biomarker 深圳大学 2018-05-22 CN disclosed
CN-107208019-A Methods and arrays for the generation and sequencing of nucleic acid monoclonal clusters 伊鲁米纳剑桥有限公司 2017-09-26 CN disclosed
CN-107206037-A Chrysanthemum extract and application thereof I.B.R.以色列生物科技研究有限公司 2017-09-26 CN disclosed
CN-107155304-A Use of Secoisolariciresinol Diglucoside (SDG) and related compounds for protecting against radiation and chemical damage 宾夕法尼亚大学董事会 2017-09-12 CN disclosed
CN-106999512-A Novel formulations 葛兰素史克消费保健(美国) 控股有限责任公司 2017-08-01 CN disclosed
CN-105848681-A Oxidized extracellular DNA moieties as stress biomarkers and methods of use thereof 安娜·巴兰诺娃 2016-08-10 CN disclosed
CN-104830930-A Nucleoside drug intermediate 2 '-deoxyguanosine production method LESHAN RECONDEX BIOPHARMACEUTICAL CO LTD 2015-08-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10577481-B2 Polymer OGG1, PCNA, DCLRE1A PNP 1320/4885CYP3A4 3862/4885MAPT 4627/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.