Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3066164 | 0.89 | POLB (0.41) | PNPCYP3A4MAPTPOLBTLR7 | |
| SCHEMBL21779018 | 0.89 | PNP (0.55) | PNPCYP3A4MAPTPOLBTLR7 | |
| SCHEMBL114652 | 0.89 | PNP (0.55) | PNPCYP3A4MAPTPOLBTLR7 | |
| SCHEMBL195548 | 0.89 | PNP (0.55) | PNPCYP3A4MAPTPOLBTLR7 | |
| Phosphoric Acid SCHEMBL9013988 | 0.85 | PNP (0.52) | PNPCYP3A4MAPTPOLBTLR7 | |
| SCHEMBL655858 | 0.80 | PNP (0.65) | PNPCYP3A4MAPTPOLBADRB1 | |
| SCHEMBL655857 | 0.80 | PNP (0.65) | PNPCYP3A4MAPTPOLBADRB1 | |
| SCHEMBL657361 | 0.78 | PNP (0.54) | PNPCYP3A4MAPTPOLBADRB1 | |
| SCHEMBL18952860 | 0.78 | PNP (0.54) | PNPCYP3A4MAPTPOLBADRB1 | |
| SCHEMBL14543297 | 0.78 | PNP (0.54) | PNPCYP3A4MAPTPOLBADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100266723-A1 | METHODS FOR FORMULATING AND CUSTOMIZING A MICRONUTRIENT SUPPLEMENT | METAMETRIX, INC. (US) | 2010-10-21 | — | — | US | disclosed |
| WO-2006060445-A2 | METHODS FOR FORMULATING AND CUSTOMIZING A MICRONUTRIENT SUPPLEMENT | METAMETRIX, INC. (US) | 2006-06-08 | — | — | WO | disclosed |