Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11454492 | 0.87 | POLB (0.49) | MEN1KMT2APOLBPIM1PIM3 | |
| SCHEMBL11465420 | 0.86 | ALDH1A1 (0.66) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL11605251 | 0.86 | KDM4E (0.46) | MEN1KMT2APIM1FLT3PIM3 | |
| SCHEMBL11446935 | 0.86 | KDM4E (0.46) | DRD3MEN1KMT2APIM1FLT3 | |
| SCHEMBL4928911 | 0.85 | ALDH1A1 (0.58) | DRD3MEN1KMT2APOLBHRH3 | |
| SCHEMBL11448262 | 0.84 | HTR1A (0.58) | DRD3MEN1KMT2APOLB | |
| SCHEMBL11605256 | 0.84 | KMT2A (0.54) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11454827 | 0.84 | SIRT2 (0.51) | DRD3MEN1KMT2APOLBKDM4E | |
| SCHEMBL11497813 | 0.84 | ALDH1A1 (0.55) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL4931903 | 0.83 | ADRA1A (0.54) | DRD3MEN1KMT2AHRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |