Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 4/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11467754 | 0.94 | PTGES (0.35) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11485810 | 0.90 | MAPT (0.45) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11711759 | 0.83 | ALOX5 (0.44) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11468308 | 0.80 | CYP1A2 (0.37) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11466667 | 0.77 | PTGES (0.32) | — | |
| SCHEMBL11469647 | 0.77 | PTGES (0.39) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11484230 | 0.75 | SRC (0.35) | — | |
| SCHEMBL11483025 | 0.74 | PTGES (0.41) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11468266 | 0.74 | MAPT (0.36) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11864433 | 0.74 | PTGES (0.41) | MAPTKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |