Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11473432 | 0.98 | TGFBR1 (0.50) | TGFBR1PDE10AATMTGFBR2RAB9A | |
| Bromide SCHEMBL9699922 | 0.92 | PDE10A (0.56) | TGFBR1PDE10AATMTGFBR2RAB9A | |
| SCHEMBL11474839 | 0.84 | RAB9A (0.53) | TGFBR1PDE10AATMTGFBR2RAB9A | |
| SCHEMBL9436258 | 0.84 | TGFBR1 (0.69) | TGFBR1PDE10AATMTGFBR2RAB9A | |
| SCHEMBL11473380 | 0.80 | PDE10A (0.51) | TGFBR1PDE10AATMTGFBR2RAB9A | |
| SCHEMBL7343693 | 0.78 | TGFBR1 (0.65) | TGFBR1PDE10ATGFBR2SMN1; SMN2KDM4E | |
| SCHEMBL11482604 | 0.77 | MAPT (0.59) | TGFBR1PDE10AATMTGFBR2RAB9A | |
| SCHEMBL14278537 | 0.77 | TGFBR1 (0.52) | TGFBR1PDE10ATGFBR2RAB9ANPC1 | |
| SCHEMBL15452608 | 0.76 | TGFBR1 (0.72) | TGFBR1PDE10AATMRAB9ANPC1 | |
| SCHEMBL9524935 | 0.76 | TGFBR1 (0.50) | TGFBR1PDE10AATMTGFBR2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186205-A | ANTIARTHRITIC AGENTS | SMITHKLINE CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |