Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.59 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 2/20 | 0.49 |
| ▸ | FERMT2 | Q96AC1 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15452534 | 0.88 | PRNP (0.57) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL27303567 | 0.85 | PRNP (0.51) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL27295461 | 0.84 | NR4A2 (0.51) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL8544136 | 0.83 | PRNP (0.52) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL12657025 | 0.81 | PRNP (0.47) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL9397349 | 0.81 | PRNP (0.55) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL8539034 | 0.81 | PRNP (0.53) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL5401241 | 0.80 | NR4A2 (0.50) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL8541256 | 0.80 | PRNP (0.54) | PRNPRXFP1KDM4ENR4A2SOS2 | |
| SCHEMBL2121573 | 0.80 | PRNP (0.46) | PRNPRXFP1KDM4ENR4A2SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110045100-A1 | Antimalarial Quinolines and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2011-02-24 | — | — | US | disclosed |
| WO-2009148659-A2 | ANTIMALARIAL QUINOLINES AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110045100-A1 | Antimalarial Quinolines and Methods of Use Thereof | NQO2, QTRT1, QTRT2 | PRNP 2589/4885RXFP1 3727/4885KDM4E 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.