Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.57 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | WEE1 | P30291 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11478035 | 0.88 | ERAP1 (0.74) | ERAP1MAPTNPC1CALM1PKM | |
| SCHEMBL11480049 | 0.85 | MAOB (0.71) | ERAP1MAPTNPC1RAB9AMAOB | |
| SCHEMBL5425943 | 0.85 | ERAP1 (0.79) | ERAP1MAPTNPC1RAB9ACALM1 | |
| SCHEMBL7807865 | 0.85 | CA9 (0.56) | ERAP1MAPTNPC1RAB9AMAOB | |
| SCHEMBL29466790 | 0.83 | MAOB (0.70) | ERAP1CALM1PKMMAOBCYP1A2 | |
| SCHEMBL669375 | 0.83 | MAOB (0.70) | ERAP1CALM1PKMMAOBCYP1A2 | |
| SCHEMBL11479069 | 0.81 | MAOB (0.71) | MAPTNPC1RAB9AMAOBMAOA | |
| SCHEMBL31675834 | 0.79 | ESR1 (0.82) | ERAP1MAPTNPC1CALM1PKM | |
| SCHEMBL5082203 | 0.79 | ESR1 (0.82) | ERAP1MAPTNPC1CALM1PKM | |
| SCHEMBL8493787 | 0.78 | PDE2A (0.56) | MAPTNPC1RAB9AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4230850-A | HYPOTENSIVE AGENTS, VASODILATION | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1980-10-28 | — | — | US | disclosed |