Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28823850 | 0.78 | HPGD (0.53) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL14875894 | 0.75 | HDAC1 (0.56) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL14875819 | 0.74 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL18135116 | 0.74 | HPGD (0.52) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL14876043 | 0.72 | HPGD (0.46) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL633995 | 0.71 | KMT2A (0.76) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL18135095 | 0.70 | HPGD (0.47) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL2725642 | 0.70 | HTR6 (0.59) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL6984395 | 0.69 | GLO1 (0.56) | KDM4EALDH1A1HPGDARKMT2A | |
| SCHEMBL6982951 | 0.69 | GLO1 (0.56) | KDM4EALDH1A1HPGDARKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4237300-A | CHEMICAL INTERMEDIATES FOR IMIDAZO(1,2-A)PYRIDINE ANTHELMINTIC AGENTS AS WELL AS BEING A FUNGICIDE | MERCK & CO., INC. (US) | 1980-12-02 | — | — | US | disclosed |
| US-4177274-A | ANTHELMINTICS | MERCK & CO., INC. (US) | 1979-12-04 | — | — | US | disclosed |
| US-4096264-A | ANTHELMINTICS | MERCK & CO., INC. (US) | 1978-06-20 | — | — | US | disclosed |