Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153912 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1TSHRNFE2L2GAA | |
| SCHEMBL2128908 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1TSHRNFE2L2GAA | |
| SCHEMBL18537139 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2TSHRNFE2L2GAAALDH1A1 | |
| SCHEMBL31438691 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2NFE2L2ALDH1A1HPGDMAPK1 | |
| SCHEMBL8417921 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2NFE2L2ALDH1A1HPGDMAPK1 | |
| SCHEMBL5133757 | 0.77 | NFE2L2 (0.40) | SMN1; SMN2L3MBTL1TSHRNFE2L2GAA | |
| SCHEMBL1884282 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2NFE2L2GAAALDH1A1NPC1 | |
| SCHEMBL5164827 | 0.76 | NFE2L2 (0.44) | SMN1; SMN2TSHRNFE2L2ALDH1A1RAB9A | |
| SCHEMBL7646522 | 0.75 | NR3C2 (0.38) | SMN1; SMN2L3MBTL1TSHRNFE2L2GAA | |
| SCHEMBL7713403 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1TSHRNFE2L2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4181665-A | INTERMEDIATES FOR AMINO DERIVATIVES POSSESSING HYPOTENSIVE AND CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1980-01-01 | — | — | US | disclosed |