Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.51 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468343 | 0.93 | ADRB2 (0.59) | SMN1; SMN2KDM4ETDP1ADRB2ADRB1 | |
| SCHEMBL11468342 | 0.93 | ADRB2 (0.59) | SMN1; SMN2KDM4ETDP1ADRB2ADRB1 | |
| SCHEMBL11467406 | 0.88 | ADRB2 (0.61) | SMN1; SMN2KDM4EGAATDP1ADRB2 | |
| SCHEMBL11467407 | 0.88 | ADRB2 (0.61) | SMN1; SMN2KDM4EGAATDP1ADRB2 | |
| Acetic Acid SCHEMBL11468057 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4EGAATDP1ADRB2 | |
| Bromide SCHEMBL11470044 | 0.87 | ADRB2 (0.59) | SMN1; SMN2KDM4EGAATDP1ADRB2 | |
| Bromide SCHEMBL11470045 | 0.87 | ADRB2 (0.59) | SMN1; SMN2KDM4EGAATDP1ADRB2 | |
| Arbutamine SCHEMBL7870502 | 0.86 | ADRB2 (0.58) | KDM4EADRB2ADRB1CYP3A4TSHR | |
| SCHEMBL10604963 | 0.82 | ADRB2 (0.67) | ADRB2ADRB1ALDH1A1LMNANPSR1 | |
| SCHEMBL11482320 | 0.79 | ADRB2 (0.52) | ADRB2ADRB1ALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007716-A1 | R-N-(2-phenyl-2-hydroxyethyl)-3-phenylpropyl amines, their formulations, use and preparation | ELI LILLY AND COMPANY (US) | 1980-02-06 | — | — | EP | disclosed |