SCHEMBL11483

SCHEMBL11483

C#CCCCC(=O)NC(C)C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.55
FAAH O00519 1/20 0.55
MAPK1 P28482 1/20 0.55
KMT2A Q03164 1/20 0.55
CYP1A2 P05177 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP3A4 P08684 1/20 0.46
CNR1 P21554 1/20 0.44
HSD17B10 Q99714 2/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.39
HPGD P15428 3/20 0.38
NLRP1 Q9C000 1/20 0.38
ALDH1A1 P00352 2/20 0.37
KDM4E B2RXH2 2/20 0.37
EPHX2 P34913 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
ALOX5 P09917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27173927 0.83 FAAH (0.50) MEN1FAAHMAPK1KMT2ACYP1A2
SCHEMBL27173926 0.83 FAAH (0.50) MEN1FAAHMAPK1KMT2ACYP1A2
SCHEMBL5909190 0.80 FAAH (0.71) MEN1FAAHMAPK1KMT2AHSD17B10
SCHEMBL12934925 0.80 FAAH (0.78) MEN1FAAHMAPK1KMT2AHSD17B10
SCHEMBL12934928 0.78 FAAH (0.83) MEN1FAAHMAPK1KMT2ASMN1; SMN2
SCHEMBL12934924 0.78 FAAH (0.83) MEN1FAAHMAPK1KMT2ASMN1; SMN2
SCHEMBL12934930 0.78 FAAH (0.83) MEN1FAAHMAPK1KMT2ASMN1; SMN2
SCHEMBL26503549 0.78 CYP1A2 (0.42) MEN1FAAHMAPK1KMT2ACYP1A2
SCHEMBL15489317 0.77 CYP1A2 (0.45) MEN1MAPK1KMT2ACYP1A2CYP2D6
SCHEMBL3084079 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2491037-A1 COMPOUNDS Respivert Limited (GB) 2012-08-29 EP claimed
WO-2011048111-A1 COMPOUNDS RESPIVERT LIMITED (GB) 2011-04-28 WO claimed
US-20180118754-A1 COMPOUNDS RESPIVERT LTD. (GB) 2018-05-03 US disclosed
US-20180118754-A1 COMPOUNDS RESPIVERT LTD. (GB) 2018-05-03 US disclosed
US-9834560-B2 Compounds RESPIVERT LTD. (GB) 2017-12-05 US disclosed
US-9834560-B2 Compounds RESPIVERT LTD. (GB) 2017-12-05 US disclosed
US-20160264583-A1 COMPOUNDS RESPIVERT LTD. (GB) 2016-09-15 US disclosed
US-20160264583-A1 COMPOUNDS RESPIVERT LTD. (GB) 2016-09-15 US disclosed
WO-2016097158-A1 METHOD OF TREATING OVARIAN CANCER PSIOXUS THERAPEUTICS LIMITED (GB) 2016-06-23 WO disclosed
US-9321773-B2 Compounds Respivert, Ltd. (GB) 2016-04-26 US disclosed
US-9321773-B2 Compounds Respivert, Ltd. (GB) 2016-04-26 US disclosed
EP-3007711-A2 A DOSING REGIME AND FORMULATIONS FOR TYPE B ADENOVIRUSES Psioxus Therapeutics Limited (GB) 2016-04-20 EP disclosed
WO-2014198852-A2 A DOSING REGIME AND FORMULATIONS FOR TYPE B ADENOVIRUSES PSIOXUS THERAUPEUTICS LIMITED (GB) 2014-12-18 WO disclosed
US-20140249164-A1 COMPOUNDS RESPIVERT LTD (GB) 2014-09-04 US disclosed
US-20140249164-A1 COMPOUNDS RESPIVERT LTD (GB) 2014-09-04 US disclosed
US-8741909-B2 PI3 kinase inhibitors RESPIVERT LTD. (GB) 2014-06-03 US disclosed
US-8741909-B2 PI3 kinase inhibitors RESPIVERT LTD. (GB) 2014-06-03 US disclosed
EP-2491037-B1 QUINAZOLIN-4(3H)-ONE DERIVATIVES USED AS PI3 KINASE INHIBITORS RESPIVERT LTD (GB) 2014-04-30 EP disclosed
US-20120208799-A1 COMPOUNDS RESPIVERT LTD (GB) 2012-08-16 US disclosed
US-20120208799-A1 COMPOUNDS RESPIVERT LTD (GB) 2012-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160264583-A1 COMPOUNDS LTC4S, CYP11B2, LTB4R2 MEN1 1550/4885FAAH 921/4885MAPK1 3218/4885
US-20140249164-A1 COMPOUNDS LTC4S, CYP11B2, LTB4R2 MEN1 1550/4885FAAH 921/4885MAPK1 3218/4885
US-20120208799-A1 COMPOUNDS LTC4S, CYP11B2, LTB4R2 MEN1 1550/4885FAAH 921/4885MAPK1 3218/4885
US-20180118754-A1 COMPOUNDS LTC4S, CYP11B2, LTB4R2 MEN1 1550/4885FAAH 921/4885MAPK1 3218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.