SCHEMBL1148355

SCHEMBL1148355

CN(C(=O)c1cc(Cl)ccc1NC(=O)C1CC(OS(=O)(=O)c2cccc([N+](=O)[O-])c2)=NN1c1ncccc1Cl)C1CC1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR17 Q13304 5/20 0.35
FLT1 P17948 1/20 0.34
FLT4 P35916 1/20 0.34
KDR P35968 1/20 0.34
P2RY2 P41231 3/20 0.34
LMNA P02545 2/20 0.34
HTT P42858 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MAPT P10636 1/20 0.33
P2RX7 Q99572 1/20 0.33
F2 P00734 1/20 0.33
RBP4 P02753 1/20 0.32
EPHX2 P34913 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
MALT1 Q9UDY8 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1148362 0.94 RBP4 (0.33) GPR17FLT1FLT4KDRP2RY2
SCHEMBL1147729 0.91 GPR17 (0.34) GPR17P2RY2HTTSMN1; SMN2MAPT
SCHEMBL1148228 0.90 GPR17 (0.33) GPR17FLT1FLT4KDRP2RY2
SCHEMBL1148457 0.89 PPARG (0.34) LMNAHTTSMN1; SMN2MAPTF2
SCHEMBL590541 0.86 RBP4 (0.38) LMNAHTTMAPTRBP4MEN1
SCHEMBL1147738 0.86 GPR17 (0.37) GPR17FLT1FLT4KDRP2RY2
SCHEMBL1148358 0.86 GPR17 (0.36) GPR17FLT1FLT4KDRP2RY2
SCHEMBL1148273 0.85 MALT1 (0.36) GPR17P2RY2LMNAHTTSMN1; SMN2
SCHEMBL1148238 0.84 P2RY2 (0.31) GPR17P2RY2MALT1
SCHEMBL1148464 0.81 GPR17 (0.38) GPR17FLT1FLT4KDRP2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-02-10 US disclosed
EP-2264021-A1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND SQOR, NOX5, NOX3 GPR17 4172/4885FLT1 4156/4885FLT4 3780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.