SCHEMBL1148438

SCHEMBL1148438

Cc1cc(Cl)cc(C(=O)NCC2CC2)c1NC(=O)C1CC(Br)=NN1c1ncccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.42
MALT1 Q9UDY8 4/20 0.42
CHRM1 P11229 3/20 0.37
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM5 P08912 1/20 0.37
CHRM3 P20309 1/20 0.37
KCNH2 Q12809 3/20 0.37
MAPK14 Q16539 4/20 0.36
DRD4 P21917 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL591394 0.92 P2RX7 (0.43) P2RX7MALT1CHRM1KCNH2MEN1
SCHEMBL1149097 0.91 MALT1 (0.42) P2RX7MALT1CHRM1CHRM2CHRM4
SCHEMBL1148395 0.89 MALT1 (0.43) MALT1DRD4
SCHEMBL9290071 0.87 MALT1 (0.42) MALT1
SCHEMBL10286763 0.87 MALT1 (0.44) MALT1DRD4
SCHEMBL591382 0.86 CNR2 (0.45) P2RX7MALT1CHRM1KCNH2
SCHEMBL15085649 0.85 P2RX7 (0.38) P2RX7MALT1CHRM1CHRM2CHRM4
SCHEMBL590823 0.85 MALT1 (0.41) MALT1DRD4
SCHEMBL591109 0.85 P2RX7 (0.41) P2RX7MALT1CHRM1KCNH2
SCHEMBL1148415 0.85 MALT1 (0.37) P2RX7MALT1CHRM1CHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8481744-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2013-07-09 US disclosed
EP-2264021-B1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-06-26 EP disclosed
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-02-10 US disclosed
EP-2264021-A1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND SQOR, NOX5, NOX3 P2RX7 3091/4885MALT1 3967/4885CHRM1 3809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.