SCHEMBL1148615

SCHEMBL1148615

CNC(=O)c1cc(C#N)cc(C)c1NC(=O)C1CC(OS(=O)(=O)c2cccc([N+](=O)[O-])c2)=NN1c1ncccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.35
GPR17 Q13304 5/20 0.35
P2RY2 P41231 1/20 0.35
ALPL P05186 1/20 0.33
ALPI P09923 1/20 0.33
PRMT5 O14744 1/20 0.33
WDR77 Q9BQA1 1/20 0.33
MAPT P10636 2/20 0.33
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
GAA P10253 1/20 0.32
HPGD P15428 1/20 0.32
P2RX7 Q99572 2/20 0.32
MALT1 Q9UDY8 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
FLT1 P17948 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1148188 0.94 GPR17 (0.33) F2GPR17P2RY2ALPLALPI
SCHEMBL1148464 0.92 GPR17 (0.38) F2GPR17P2RY2PRMT5WDR77
SCHEMBL1148420 0.89 F2 (0.35) F2ALPLALPIMAPTALDH1A1
SCHEMBL1148316 0.88 MALT1 (0.34) F2ALDH1A1HTTKMT2AMALT1
SCHEMBL1148434 0.88 MALT1 (0.35) KMT2AMALT1
SCHEMBL1148275 0.86 MALT1 (0.36) GPR17P2RY2MAPTALDH1A1HTT
SCHEMBL1148234 0.85 MALT1 (0.35) KMT2AMALT1
SCHEMBL1147730 0.84 F2 (0.36) F2GPR17P2RY2PRMT5WDR77
SCHEMBL15085560 0.83 SMN1; SMN2 (0.32) MAPTALDH1A1HTTMEN1KMT2A
SCHEMBL1148360 0.83 GPR17 (0.36) F2GPR17P2RY2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2264021-B1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-06-26 EP disclosed
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-02-10 US disclosed
EP-2264021-A1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND SQOR, NOX5, NOX3 F2 610/4885GPR17 4172/4885P2RY2 3126/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.