Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489452 | 0.88 | LMNA (0.49) | CYP19A1TP53KDM4ETSHRCYP2A6 | |
| SCHEMBL11495720 | 0.87 | CYP19A1 (0.61) | CYP19A1TP53CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL11492775 | 0.86 | ADRA2C (0.44) | CYP19A1TP53KDM4ETSHRALDH1A1 | |
| SCHEMBL11492519 | 0.86 | HMOX1 (0.59) | CYP19A1CYP11B1CYP11B2LMNASMN1; SMN2 | |
| SCHEMBL11494331 | 0.86 | CYP19A1 (0.68) | CYP19A1CYP11B1CYP11B2LMNASMN1; SMN2 | |
| SCHEMBL11494415 | 0.83 | CYP19A1 (0.50) | CYP19A1TSHRCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL5758394 | 0.81 | CYP19A1 (0.53) | CYP19A1LMNASMN1; SMN2 | |
| SCHEMBL28164874 | 0.79 | CYP19A1 (0.50) | CYP19A1TSHRCYP11B1CYP11B2LMNA | |
| SCHEMBL11488859 | 0.79 | FFAR1 (0.53) | TP53KDM4EALDH1A1CYP3A4LMNA | |
| SCHEMBL11630824 | 0.78 | CYP19A1 (0.53) | CYP19A1TP53KDM4ETSHRCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |