Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11490100 | 0.87 | POLB (0.53) | POLBGAAHPGDMDM2EPHX2 | |
| SCHEMBL11493894 | 0.80 | TMEM97 (0.44) | POLBGAAHPGDLMNAMAPT | |
| SCHEMBL11495362 | 0.77 | HTT (0.49) | POLBHPGDLMNAMEN1KMT2A | |
| SCHEMBL11490044 | 0.77 | SIGMAR1 (0.42) | POLBGAACYP2C19CYP2C9LMNA | |
| SCHEMBL11491362 | 0.76 | HPGD (0.51) | POLBGAAHPGDCYP1A2CYP2C19 | |
| SCHEMBL11490144 | 0.74 | HTT (0.56) | HPGDMEN1KMT2ANPSR1 | |
| SCHEMBL11494197 | 0.73 | CNR2 (0.48) | POLBGAAHPGDLMNAMEN1 | |
| SCHEMBL23130338 | 0.73 | POLB (1.00) | POLBGAAHPGDEPHX2EPHX1 | |
| SCHEMBL7568943 | 0.71 | EPHX2 (0.64) | POLBHPGDEPHX2EPHX1MAPT | |
| SCHEMBL11495723 | 0.70 | USP2 (0.53) | POLBHPGDCYP2C19CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4202832-A | ANTILIPEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-05-13 | — | — | US | disclosed |