Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11475291 | 0.98 | SIGMAR1 (0.45) | SIGMAR1ALDH1A1KDM4EHSD17B10GAA | |
| Oxalic Acid SCHEMBL11490187 | 0.86 | SLC18A3 (0.39) | SIGMAR1SLC18A3 | |
| SCHEMBL11476416 | 0.84 | SLC18A3 (0.40) | SIGMAR1SLC18A3 | |
| SCHEMBL11478493 | 0.80 | OPRM1 (0.46) | SLC18A3 | |
| Oxalic Acid SCHEMBL11490161 | 0.80 | OPRM1 (0.43) | ALDH1A1KDM4ESLC18A3POLBSMN1; SMN2 | |
| Oxalic Acid SCHEMBL11478570 | 0.79 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1KDM4EHSD17B10GAA | |
| Oxalic Acid SCHEMBL11490220 | 0.79 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL11477995 | 0.77 | OPRM1 (0.44) | SLC18A3POLBSMN1; SMN2 | |
| SCHEMBL11475284 | 0.77 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL11471888 | 0.77 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1KDM4EHSD17B10SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |