Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25563998 | 0.94 | KDM4E (0.41) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL11492424 | 0.84 | KMT2A (0.38) | CYP17A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL25564028 | 0.80 | CES2 (0.42) | KDM4EMEN1KMT2AMAPTHTT | |
| SCHEMBL20306573 | 0.79 | KDM4E (0.41) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL18408916 | 0.78 | CYP2C19 (0.48) | KMT2AMAPTMAPK1RIPK1KCNN4 | |
| SCHEMBL5571854 | 0.78 | CYP2C19 (0.48) | KMT2AMAPTMAPK1RIPK1KCNN4 | |
| SCHEMBL14827342 | 0.78 | KDM4E (0.38) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14827410 | 0.78 | RIPK1 (0.45) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL25564005 | 0.77 | CYP4F2 (0.37) | KDM4ERIPK1 | |
| SCHEMBL25564002 | 0.77 | KCNN4 (0.40) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |