Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11462243 | 0.83 | NPC1 (0.39) | LMNAATMPDE2A | |
| SCHEMBL11459397 | 0.82 | ALDH1A1 (0.44) | — | |
| SCHEMBL11486063 | 0.80 | LMNA (0.49) | GRIA4LMNATSHRTP53TYR | |
| SCHEMBL19464437 | 0.76 | TSHR (0.46) | GRIA4LMNATSHRTP53TYR | |
| SCHEMBL20990642 | 0.76 | GRIA4 (0.42) | GRIA4LMNATSHRTP53TYR | |
| SCHEMBL30943788 | 0.75 | TSHR (0.41) | GRIA4LMNATSHRTP53TYR | |
| SCHEMBL26331113 | 0.75 | TRPA1 (0.38) | LMNAACHE | |
| SCHEMBL9555071 | 0.74 | TAAR1 (0.43) | LMNA | |
| SCHEMBL11494429 | 0.73 | TSHR (0.39) | GRIA4LMNATSHRTP53TYR | |
| SCHEMBL8053565 | 0.72 | GRIA4 (0.47) | GRIA4LMNATSHRTP53TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4241058-A | INSECTICIDES, MITICIDES, SYSTEMIC | HOFFMANN-LA ROCHE INC. (US) | 1980-12-23 | — | — | US | disclosed |
| EP-0005541-A2 | Substituted piperidine, morpholine or piperidone derivatives, fungicides containing these compounds, process for their preparation and their use, and the use of these compounds as fungicides | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-11-28 | — | — | EP | disclosed |