Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | SCN1A | P35498 | 1/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11487383 | 0.92 | CYP2D6 (0.52) | KDM4ECHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL11489482 | 0.91 | CYP2D6 (0.50) | KDM4ECHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL11489246 | 0.87 | USP2 (0.51) | KDM4ECHRM4CHRM5CHRM3OPRM1 | |
| SCHEMBL11488904 | 0.83 | ALDH1A1 (0.44) | KDM4ECHRM2CHRM1KCNH2HTR1A | |
| SCHEMBL11487644 | 0.81 | LMNA (0.49) | KDM4ECHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL11492973 | 0.81 | KCNH2 (0.61) | KDM4ECHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL11494400 | 0.81 | CHRM4 (0.48) | KDM4ECHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL11489627 | 0.81 | CHRM3 (0.46) | KDM4ECHRM3KCNH2LMNAALDH1A1 | |
| SCHEMBL8967625 | 0.80 | CHRM2 (0.72) | KDM4ECHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL11492203 | 0.80 | CHRM2 (0.47) | KDM4ECHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |