Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11488179 | 0.84 | HTT (0.40) | CYP17A1FFAR1POLB | |
| SCHEMBL11485445 | 0.84 | HTR2A (0.55) | SLC6A4TAAR1SLC6A2HTR2AHRH1 | |
| SCHEMBL11606556 | 0.83 | MAPK1 (0.38) | CYP17A1 | |
| SCHEMBL11496377 | 0.82 | SLC6A4 (0.45) | SLC6A4TAAR1SLC6A2HTR2AHRH1 | |
| SCHEMBL11496245 | 0.81 | RIPK1 (0.35) | CYP17A1FFAR1POLB | |
| SCHEMBL11494471 | 0.81 | HTT (0.38) | CYP17A1 | |
| SCHEMBL11487006 | 0.81 | MITF (0.38) | CYP17A1 | |
| SCHEMBL11492769 | 0.80 | ALDH1A1 (0.38) | SLC6A4SLC6A2HTR2AHRH1CYP17A1 | |
| SCHEMBL13792137 | 0.79 | ALDH1A1 (0.41) | CYP17A1FFAR1 | |
| SCHEMBL11494252 | 0.79 | TSHR (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |