SCHEMBL11499495

SCHEMBL11499495

Clc1cccc(C(Br)Br)c1Cl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.56
PNMT P11086 2/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56
NFKB1 P19838 1/20 0.56
LMNA P02545 2/20 0.54
ALDH1A1 P00352 2/20 0.54
GLA P06280 1/20 0.54
IDO1 P14902 3/20 0.44
TDO2 P48775 1/20 0.44
TSHR P16473 3/20 0.42
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
P2RX7 Q99572 1/20 0.38
CYP2A6 P11509 1/20 0.38
KCNH2 Q12809 1/20 0.37
TAAR1 Q96RJ0 1/20 0.35
S100B P04271 1/20 0.34
ITGB3 P05106 1/20 0.34
ITGAV P06756 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10980261 0.81 CYP1A2 (0.63) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL9677445 0.79 TSHR (0.47) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL1570072 0.78 P2RX7 (0.37) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL7183711 0.78 CYP1A2 (0.39) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL10765113 0.78 PNMT (0.48) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL1872442 0.77 CYP1A2 (0.58) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL28773697 0.76 P2RX7 (0.36) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL22124021 0.76 CFD (0.46) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL14320959 0.76 PNMT (0.47) CYP1A2PNMTCYP3A4CYP2D6NFKB1
SCHEMBL21296457 0.76 PNMT (0.47) CYP1A2PNMTCYP3A4CYP2D6NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107043321-B Method for high-selectivity synthesis of 2, 3-dichlorobenzaldehyde 连云港市工业投资集团有限公司 2021-01-15 CN claimed
CN-107043321-B Method for high-selectivity synthesis of 2, 3-dichlorobenzaldehyde 连云港市工业投资集团有限公司 2021-01-15 CN disclosed
CN-107043321-B Method for high-selectivity synthesis of 2, 3-dichlorobenzaldehyde 连云港市工业投资集团有限公司 2021-01-15 CN disclosed
US-4189598-A INSECTICIDES., MITICIDE ZOECON CORPORATION (US) 1980-02-19 US disclosed