Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5704861 | 0.89 | HCAR2 (0.53) | KDM4EHCAR2MAPK1CYP1A2 | |
| SCHEMBL2347397 | 0.89 | HCAR2 (0.53) | KDM4EHCAR2MAPK1CYP1A2 | |
| SCHEMBL11757511 | 0.80 | PTGS2 (0.47) | PTGS2KDM4EMAPTALDH1A1HCAR2 | |
| SCHEMBL11757521 | 0.80 | PTGS2 (0.47) | PTGS2KDM4EMAPTALDH1A1HCAR2 | |
| SCHEMBL28096265 | 0.76 | KDM4E (0.42) | KDM4EMAPTALDH1A1MAPK1GAA | |
| SCHEMBL9721540 | 0.76 | PTGS2 (0.43) | PTGS2KDM4EMAPTALDH1A1ACP3 | |
| SCHEMBL11439819 | 0.76 | ATG4B (0.45) | KDM4EALDH1A1MAPK1CYP1A2PKM | |
| SCHEMBL11439822 | 0.76 | ATG4B (0.45) | KDM4EALDH1A1MAPK1CYP1A2PKM | |
| SCHEMBL5229228 | 0.76 | TDP1 (0.48) | MAPTHCAR2MAPK1CYP1A2 | |
| SCHEMBL5229224 | 0.76 | TDP1 (0.48) | MAPTHCAR2MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0020230-A2 | p-Biphenyl-4-methyl-2-butenoic acids, process for their preparation, pharmaceutical compositions containing them and their use | PIERRE FABRE S.A. (FR) | 1980-12-10 | — | — | EP | disclosed |