SCHEMBL1150352

SCHEMBL1150352

[c]1cccnc1C1CCCCO1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 1/20 0.33
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
PDE10A Q9Y233 2/20 0.31
MAPK8 P45983 1/20 0.31
MAPK9 P45984 1/20 0.31
MAPK10 P53779 1/20 0.31
KDM4E B2RXH2 2/20 0.31
KCNH2 Q12809 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
GAA P10253 1/20 0.31
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8924463 0.77
SCHEMBL23774708 0.76 PDE8B (0.36) HRH1POLBMAPTPDE10AMAPK8
SCHEMBL1162066 0.76 KDM4E (0.35) KDM4EGAAALDH1A1
SCHEMBL2946917 0.74 KDM4E (0.38) KDM4EGAAALDH1A1TSHRHSD17B10
SCHEMBL948754 0.73 DRD2 (0.41)
SCHEMBL944190 0.71
SCHEMBL11777192 0.70 ALDH1A1 (0.43) HRH1POLBMAPTPDE10AMAPK8
SCHEMBL1608176 0.70 KCNH2 (0.31) KCNH2HRH3GAA
SCHEMBL5930198 0.70 HRH1 (0.40) HRH1POLBMAPTPDE10AKDM4E
SCHEMBL20599464 0.69 KCNH2 (0.31) KCNH2HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2111756-B1 PEST CONTROL AGENTS MEIJI SEIKA PHARMA CO LTD (JP) 2017-08-02 EP disclosed
US-9675075-B2 Pest control composition BASF SE (DE) 2017-06-13 US disclosed
US-20140371178-A1 PEST CONTROL COMPOSITION BASF SE (DE) 2014-12-18 US disclosed
US-8859462-B2 Pest control composition MEIJI SEIKA PHARMA CO., LTD. (JP) 2014-10-14 US disclosed
US-8822501-B2 Pest control agents MEIJI SEIKA PHARMA CO., LTD. (JP) 2014-09-02 US disclosed
US-20140045778-A1 PEST CONTROL AGENTS THE KITASATO INSTITUTE (JP) 2014-02-13 US disclosed
US-8367707-B2 Pest control agents MEIJI SEIKA PHARMA CO., LTD. (JP) 2013-02-05 US disclosed
US-20110034404-A1 PEST CONTROL AGENTS MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2011-02-10 US disclosed
US-7838538-B2 Pest control agents MEIJI SEIKA KAISHA, LTD. (JP) 2010-11-23 US disclosed
US-20100113525-A1 PEST CONTROL COMPOSITION MEIJI SEIKA KAISHA, LTD. (JP) 2010-05-06 US disclosed
EP-2119361-A1 PEST CONTROL COMPOSITION Meiji Seika Kaisha, Ltd. (JP) 2009-11-18 EP disclosed
EP-2111756-A1 Pest control agents MEIJI SEIKA KAISHA LTD. (JP) 2009-10-28 EP disclosed
US-20090137634-A1 Pest control agents MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2009-05-28 US disclosed
US-7491738-B2 Pest control agents MEIJI SEIKA KAISHA, LTD. (JP) 2009-02-17 US disclosed
EP-1889540-A1 PEST CONTROL AGENT MEIJI SEIKA KAISHA LTD. (JP) 2008-02-20 EP disclosed
US-20060281780-A1 Pest control agents MEIJI SEIKA KAISHA, LTD. (JP) 2006-12-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140371178-A1 PEST CONTROL COMPOSITION CTRL, PLPBP, PCNP HRH1 458/4885POLB 4546/4885MAPT 3888/4885
US-20100113525-A1 PEST CONTROL COMPOSITION CTRL, PLPBP, PCNP HRH1 458/4885POLB 4546/4885MAPT 3888/4885
US-20060281780-A1 Pest control agents CTRL, ACHE, DDT HRH1 652/4885POLB 4667/4885MAPT 2969/4885
US-20110034404-A1 PEST CONTROL AGENTS DDT, CTRL, ACHE HRH1 1106/4885POLB 4778/4885MAPT 2529/4885
US-20140045778-A1 PEST CONTROL AGENTS DDT, CTRL, ACHE HRH1 1106/4885POLB 4778/4885MAPT 2529/4885
US-20090137634-A1 Pest control agents DDT, CTRL, ACHE HRH1 1106/4885POLB 4778/4885MAPT 2529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.