Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.68 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | CTSS | P25774 | 1/20 | 0.59 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | KLK7 | P49862 | 2/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.46 |
| ▸ | CDC25B | P30305 | 5/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.46 |
| ▸ | CDC25A | P30304 | 3/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11522841 | 0.92 | PPARA (0.64) | PPARAPPARGCTSSMMEREN | |
| SCHEMBL11525633 | 0.92 | PPARA (0.64) | PPARAPPARGCTSSMMEREN | |
| SCHEMBL11522829 | 0.92 | PPARA (0.64) | PPARAPPARGCTSSMMEREN | |
| SCHEMBL29787684 | 0.88 | PPARA (0.52) | PPARAPPARGCTSSMMEMMP9 | |
| SCHEMBL29556874 | 0.86 | PPARA (0.75) | PPARAPPARGCTSSMMEKLK7 | |
| SCHEMBL29135753 | 0.86 | PPARA (0.75) | PPARAPPARGCTSSMMEKLK7 | |
| SCHEMBL828674 | 0.85 | PPARA (0.90) | PPARAPPARGCTSSMMEKLK7 | |
| SCHEMBL17051 | 0.85 | PPARA (0.90) | PPARAPPARGCTSSMMEKLK7 | |
| SCHEMBL1132901 | 0.85 | PPARA (0.90) | PPARAPPARGCTSSMMEKLK7 | |
| SCHEMBL11569823 | 0.85 | BACE1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159263-A | INHIBIT RELEASE OF GROWTH HORMONE AND INSULIN | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-06-26 | — | — | US | disclosed |
| US-4123425-A | POLYPEPTIDES, HORMONE RELEASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-10-31 | — | — | US | disclosed |
| US-3991041-A | GROWTH HORMONE RELEASE INHIBITOR | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-11-09 | — | — | US | disclosed |
| US-3988308-A | (Tyr3, Tyr14)-SRIF and intermediates | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-10-26 | — | — | US | disclosed |