Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.51 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11568495 | 1.00 | BACE1 (0.52) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11567669 | 0.92 | CTSK (0.53) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10877170 | 0.88 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29787684 | 0.86 | PPARA (0.52) | — | |
| SCHEMBL11505366 | 0.85 | PPARA (0.68) | — | |
| SCHEMBL24049735 | 0.85 | CTSK (0.57) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11566964 | 0.85 | CTSK (0.57) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31107818 | 0.84 | CTSK (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8530799 | 0.84 | REN (0.62) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5663757 | 0.83 | CTSS (0.58) | BACE1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4146614-A | TREATMENT OF SCHIZOPHRENIA | STATE OF MICHIGAN (US) | 1979-03-27 | — | — | US | disclosed |