Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.60 |
| ▸ | HTR1A | P08908 | 8/20 | 0.60 |
| ▸ | DRD2 | P14416 | 8/20 | 0.60 |
| ▸ | DRD4 | P21917 | 8/20 | 0.60 |
| ▸ | HTR2A | P28223 | 8/20 | 0.60 |
| ▸ | HTR2C | P28335 | 8/20 | 0.60 |
| ▸ | HTR7 | P34969 | 8/20 | 0.60 |
| ▸ | HTR1D | P28221 | 7/20 | 0.60 |
| ▸ | DRD3 | P35462 | 7/20 | 0.60 |
| ▸ | HTR2B | P41595 | 7/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.60 |
| ▸ | HRH2 | P25021 | 6/20 | 0.60 |
| ▸ | DRD1 | P21728 | 6/20 | 0.60 |
| ▸ | DRD5 | P21918 | 6/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.60 |
| ▸ | HTR6 | P50406 | 6/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.60 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11506081 | 0.90 | OPRM1 (0.54) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL11507337 | 0.84 | HTR7 (0.62) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL14282239 | 0.82 | OPRM1 (0.76) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL11507327 | 0.82 | LMNA (0.60) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL11507328 | 0.82 | HTR7 (0.66) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL11506921 | 0.80 | LMNA (0.60) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| Penfluridol SCHEMBL28086462 | 0.78 | OPRM1 (0.69) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL11506895 | 0.78 | CCR1 (0.53) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL11508308 | 0.76 | DRD2 (0.56) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL11508526 | 0.76 | DRD2 (0.52) | OPRM1OPRK1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4175129-A | Antiemetic 1-(benzoxazolylalkyl)-piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-20 | — | — | US | disclosed |
| US-4160836-A | Antiemetic 1-(benzothiazolylalkyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-07-10 | — | — | US | disclosed |
| US-4126687-A | ANTIEMETIC, 1-(BENZIMIDAZOLYL-ALKYL)-PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |
| US-4126688-A | ANTIEMETIC 1-(BENZOTRIAZOLYL-ALKYL)-PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |
| US-4110333-A | ANTIEMETIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-08-29 | — | — | US | disclosed |
| US-4066772-A | ANTIEMETICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-01-03 | — | — | US | disclosed |