SCHEMBL1150804

SCHEMBL1150804

[O]C(=O)c1ccnc2ccsc12

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDR P35968 12/20 0.42
PDPK1 O15530 1/20 0.42
PARP1 P09874 1/20 0.42
AXL P30530 1/20 0.40
MKNK1 Q9BUB5 1/20 0.40
MKNK2 Q9HBH9 1/20 0.40
ADORA2A P29274 3/20 0.38
ADORA2B P29275 2/20 0.38
SPR P35270 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
ADORA1 P30542 1/20 0.36
MET P08581 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11277616 0.87 KDR (0.44) KDRPDPK1PARP1AXLMKNK1
SCHEMBL25201385 0.87 KDR (0.41) KDRPDPK1PARP1AXLMKNK1
SCHEMBL1497897 0.85 MEN1 (0.44) KDRPDPK1PARP1AXLMKNK1
SCHEMBL10650329 0.85 ALDH1A1 (0.44) KDRPDPK1PARP1AXLMKNK1
Hydrochloric Acid SCHEMBL6196266 0.84 MEN1 (0.43) KDRPDPK1PARP1AXLMKNK1
SCHEMBL25191211 0.81 KDR (0.38) KDRPDPK1PARP1AXLMKNK1
SCHEMBL17440429 0.81 KDR (0.45) KDRMEN1KMT2A
SCHEMBL954193 0.78 AXL (0.38) KDRPDPK1PARP1AXLMKNK1
SCHEMBL24322141 0.78 AXL (0.38) KDRPDPK1PARP1AXLMKNK1
SCHEMBL25194783 0.74 ALDH1A1 (0.35) KDRPDPK1PARP1AXLMKNK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8822501-B2 Pest control agents MEIJI SEIKA PHARMA CO., LTD. (JP) 2014-09-02 US claimed
US-20140045778-A1 PEST CONTROL AGENTS THE KITASATO INSTITUTE (JP) 2014-02-13 US claimed
US-20110034404-A1 PEST CONTROL AGENTS MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2011-02-10 US claimed
US-20100113525-A1 PEST CONTROL COMPOSITION MEIJI SEIKA KAISHA, LTD. (JP) 2010-05-06 US claimed
EP-2119361-A1 PEST CONTROL COMPOSITION Meiji Seika Kaisha, Ltd. (JP) 2009-11-18 EP claimed
EP-2111756-A1 Pest control agents MEIJI SEIKA KAISHA LTD. (JP) 2009-10-28 EP claimed
US-20090137634-A1 Pest control agents MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2009-05-28 US claimed
EP-1889540-A1 PEST CONTROL AGENT MEIJI SEIKA KAISHA LTD. (JP) 2008-02-20 EP claimed
EP-2111756-B1 PEST CONTROL AGENTS MEIJI SEIKA PHARMA CO LTD (JP) 2017-08-02 EP disclosed
US-9675075-B2 Pest control composition BASF SE (DE) 2017-06-13 US disclosed
US-20140371178-A1 PEST CONTROL COMPOSITION BASF SE (DE) 2014-12-18 US disclosed
US-8859462-B2 Pest control composition MEIJI SEIKA PHARMA CO., LTD. (JP) 2014-10-14 US disclosed
US-8822501-B2 Pest control agents MEIJI SEIKA PHARMA CO., LTD. (JP) 2014-09-02 US disclosed
US-20140045778-A1 PEST CONTROL AGENTS THE KITASATO INSTITUTE (JP) 2014-02-13 US disclosed
US-7838538-B2 Pest control agents MEIJI SEIKA KAISHA, LTD. (JP) 2010-11-23 US disclosed
US-20100113525-A1 PEST CONTROL COMPOSITION MEIJI SEIKA KAISHA, LTD. (JP) 2010-05-06 US disclosed
EP-2119361-A1 PEST CONTROL COMPOSITION Meiji Seika Kaisha, Ltd. (JP) 2009-11-18 EP disclosed
EP-2111756-A1 Pest control agents MEIJI SEIKA KAISHA LTD. (JP) 2009-10-28 EP disclosed
US-20090137634-A1 Pest control agents MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2009-05-28 US disclosed
EP-1889540-A1 PEST CONTROL AGENT MEIJI SEIKA KAISHA LTD. (JP) 2008-02-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140371178-A1 PEST CONTROL COMPOSITION CTRL, PLPBP, PCNP KDR 4805/4885PDPK1 466/4885PARP1 4798/4885
US-20100113525-A1 PEST CONTROL COMPOSITION CTRL, PLPBP, PCNP KDR 4805/4885PDPK1 466/4885PARP1 4798/4885
US-20110034404-A1 PEST CONTROL AGENTS DDT, CTRL, ACHE KDR 4742/4885PDPK1 1497/4885PARP1 4885/4885
US-20140045778-A1 PEST CONTROL AGENTS DDT, CTRL, ACHE KDR 4742/4885PDPK1 1497/4885PARP1 4885/4885
US-20090137634-A1 Pest control agents DDT, CTRL, ACHE KDR 4742/4885PDPK1 1497/4885PARP1 4885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.