Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.52 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113278 | 0.90 | NOTUM (0.49) | NOTUMPRMT3ROCK1IMPDH2PLAU | |
| SCHEMBL3566775 | 0.80 | PRMT3 (0.72) | NOTUMPRMT3ROCK1IMPDH2PLAU | |
| SCHEMBL2164137 | 0.78 | PRMT3 (0.69) | NOTUMPRMT3ROCK1IMPDH2PLAU | |
| SCHEMBL14124306 | 0.76 | PRMT3 (0.66) | NOTUMPRMT3ROCK1IMPDH2PLAU | |
| SCHEMBL114094 | 0.74 | LTA4H (0.49) | NOTUMROCK1IMPDH2ROCK2 | |
| SCHEMBL115009 | 0.74 | ROCK2 (0.53) | NOTUMPRMT3ROCK1IMPDH2ROCK2 | |
| SCHEMBL19860082 | 0.74 | ROCK1 (0.60) | NOTUMPRMT3ROCK1IMPDH2ROCK2 | |
| SCHEMBL112926 | 0.74 | NOTUM (0.51) | NOTUMPRMT3ROCK1IMPDH2ROCK2 | |
| SCHEMBL113082 | 0.74 | ROCK2 (0.52) | NOTUMPRMT3ROCK1IMPDH2ROCK2 | |
| SCHEMBL16056718 | 0.73 | ROCK2 (0.56) | NOTUMPRMT3ROCK1IMPDH2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424842-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-2424857-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126626-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127329-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127330-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHAMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |