Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.66 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.54 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3566775 | 0.93 | PRMT3 (0.72) | PRMT3IMPDH2ROCK1LMNAROCK2 | |
| SCHEMBL2164137 | 0.90 | PRMT3 (0.69) | PRMT3IMPDH2ROCK1LMNAROCK2 | |
| SCHEMBL19860126 | 0.85 | PRMT3 (0.65) | PRMT3IMPDH2ROCK1ROCK2NOTUM | |
| SCHEMBL24735962 | 0.84 | IMPDH2 (0.69) | PRMT3IMPDH2ROCK1ROCK2NOTUM | |
| SCHEMBL19860123 | 0.82 | IMPDH2 (0.71) | PRMT3IMPDH2ROCK1ROCK2NOTUM | |
| SCHEMBL19860125 | 0.82 | PRMT3 (0.71) | PRMT3IMPDH2ROCK1LMNAROCK2 | |
| SCHEMBL14124401 | 0.82 | IMPDH2 (0.61) | PRMT3IMPDH2LMNAROCK2PLAU | |
| SCHEMBL21430054 | 0.81 | IMPDH2 (0.62) | PRMT3IMPDH2ROCK1ROCK2NOTUM | |
| SCHEMBL2205200 | 0.81 | LMNA (0.80) | LMNAKDM6BKDM4DKDM4CNPC1 | |
| SCHEMBL19860082 | 0.81 | ROCK1 (0.60) | PRMT3IMPDH2ROCK1LMNAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455513-B2 | Kinase inhibitors; anticarcinogenic agents; obesity, glaucoma; N-(4-(3-(isoquinolin-6-ylamino)-3-oxopropyl)phenyl)-4-methoxybenzamide | AERIE PHARMACEUTICALS, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-8455513-B2 | Kinase inhibitors; anticarcinogenic agents; obesity, glaucoma; N-(4-(3-(isoquinolin-6-ylamino)-3-oxopropyl)phenyl)-4-methoxybenzamide | AERIE PHARMACEUTICALS, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | PRMT3 1026/4885IMPDH2 2131/4885ROCK1 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.