Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 6/20 | 0.42 |
| ▸ | REN | P00797 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | FAP | Q12884 | 2/20 | 0.41 |
| ▸ | XIAP | P98170 | 2/20 | 0.41 |
| ▸ | MLX | Q9UH92 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11519144 | 0.86 | FKBP5 (0.44) | FKBP5ACERENPOLBKMT2A | |
| SCHEMBL11516346 | 0.86 | FKBP5 (0.44) | FKBP5ACERENPREPFAP | |
| SCHEMBL18681182 | 0.84 | PREP (0.43) | ACERENPREPFAPXIAP | |
| SCHEMBL18681072 | 0.84 | PREP (0.45) | ACERENPREPFAPF2 | |
| SCHEMBL10954689 | 0.84 | XIAP (0.46) | FKBP5ACERENPREPFAP | |
| SCHEMBL11517692 | 0.84 | FKBP5 (0.47) | FKBP5ACERENPOLBKMT2A | |
| SCHEMBL11518286 | 0.82 | ACE (0.44) | FKBP5ACERENPOLBPREP | |
| SCHEMBL18675240 | 0.82 | PREP (0.49) | ACERENPREPFAPF2 | |
| SCHEMBL11427419 | 0.82 | ACE (0.55) | ACERENF2KDM4ELMNA | |
| SCHEMBL11518459 | 0.81 | NPSR1 (0.47) | FKBP5ACERENKMT2APREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | claimed |
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | disclosed |