Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18088507 | 0.85 | PEPD (0.47) | ACELMNAPREPSMN1; SMN2REN | |
| SCHEMBL11515816 | 0.84 | PREP (0.66) | ACELMNAPREPSMN1; SMN2REN | |
| SCHEMBL11519144 | 0.84 | FKBP5 (0.44) | ACEFKBP5LMNAPREPREN | |
| SCHEMBL11516346 | 0.84 | FKBP5 (0.44) | ACEFKBP5LMNAPREPREN | |
| SCHEMBL11517747 | 0.82 | FKBP5 (0.43) | ACEFKBP5LMNAPREPREN | |
| SCHEMBL10656762 | 0.82 | ACE (0.53) | ACELMNAPREPSMN1; SMN2REN | |
| SCHEMBL10954689 | 0.81 | XIAP (0.46) | ACEFKBP5LMNAPREPREN | |
| SCHEMBL11517692 | 0.81 | FKBP5 (0.47) | ACEFKBP5PREPRENTSHR | |
| SCHEMBL26328139 | 0.80 | RAB9A (0.49) | FKBP5LMNASMN1; SMN2TSHRPOLB | |
| SCHEMBL11518459 | 0.80 | NPSR1 (0.47) | ACEFKBP5PREPRENFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | claimed |
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | disclosed |