SCHEMBL1151817

SCHEMBL1151817

C(=C/c1ccccc1)\CN1CCNCC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.58
HIF1A Q16665 4/20 0.58
CYP2D6 P10635 4/20 0.58
MAPK1 P28482 4/20 0.58
CYP3A4 P08684 3/20 0.58
ALDH1A1 P00352 3/20 0.58
CYP1A2 P05177 3/20 0.58
CYP2C9 P11712 3/20 0.58
OPRM1 P35372 3/20 0.58
SIGMAR1 Q99720 3/20 0.58
NPSR1 Q6W5P4 3/20 0.58
CHRM2 P08172 2/20 0.58
CHRM4 P08173 2/20 0.58
HTR1A P08908 2/20 0.58
CHRM5 P08912 2/20 0.58
ADRA2A P08913 2/20 0.58
ADORA3 P0DMS8 2/20 0.58
CHRM1 P11229 2/20 0.58
DRD2 P14416 2/20 0.58
ADRA2B P18089 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6596304 1.00 LMNA (0.58) LMNAHIF1ACYP2D6MAPK1CYP3A4
SCHEMBL9530000 1.00 LMNA (0.58) LMNAHIF1ACYP2D6MAPK1CYP3A4
SCHEMBL1151821 1.00 LMNA (0.58) LMNAHIF1ACYP2D6MAPK1CYP3A4
Fluoride SCHEMBL27904711 0.98 LMNA (0.56) LMNAHIF1ACYP2D6MAPK1CYP3A4
Hydrochloric Acid SCHEMBL3842618 0.98 LMNA (0.56) LMNAHIF1ACYP2D6MAPK1CYP3A4
Hydrochloric Acid SCHEMBL3842615 0.98 LMNA (0.56) LMNAHIF1ACYP2D6MAPK1CYP3A4
SCHEMBL9123051 0.94 LTA4H (0.59) LMNAHIF1ACYP2D6MAPK1CYP3A4
SCHEMBL11661323 0.94 LTA4H (0.59) LMNAHIF1ACYP2D6MAPK1CYP3A4
SCHEMBL27901884 0.90 LMNA (0.51) LMNAHIF1ACYP2D6MAPK1CYP3A4
SCHEMBL27901883 0.90 LMNA (0.51) LMNAHIF1ACYP2D6MAPK1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120058618-A Antitumor cinnamyl piperazine and 2-phenylbenzimidazole conjugate, and preparation method and application thereof 天津科技大学 2025-05-30 CN claimed
CN-119708027-A Method for preparing boronated carbonyl derivative 中国科学院大连化学物理研究所 2025-03-28 CN claimed
CN-110967421-B Method for detecting related substances of flunarizine hydrochloride preparation 正大青春宝药业有限公司 2022-04-12 CN claimed
CN-114276402-A Steroid derivative and application thereof in preparation of antitumor drugs 厦门大学 2022-04-05 CN claimed
CN-108003177-B Benzoxazine rifamycin derivative and preparation method and application thereof 中国医药集团总公司四川抗菌素工业研究所 2020-04-14 CN claimed
CN-110967421-A Method for detecting related substances of flunarizine hydrochloride preparation 正大青春宝药业有限公司 2020-04-07 CN claimed
EP-1568770-A2 Pharmaceutical use of compounds which bind to a mammalian \"trace amine\" receptor Oregon Health & Science University (US) 2005-08-31 EP claimed
US-20040072187-A1 Novel mammalian receptor genes and uses OREGON HEALTH & SCIENCE UNIVERSITY 2004-04-15 US claimed
WO-2002022801-A9 MAMMALIAN RECEPTOR GENES AND USES UNIV OREGON HEALTH & SCIENCE (US) 2003-07-03 WO claimed
EP-1319070-A2 MAMMALIAN RECEPTOR GENES AND USES Oregon Health & Science University (US) 2003-06-18 EP claimed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
EP-0319983-B1 ASSOCIATION OF PYRIMIDINE DERIVATIVES AND CALCIUM ANTAGONISTS TO INDUCE AND STIMULATE THE HAIR GROWTH AND TO REDUCE HAIR LOSS L'OREAL (FR) 1992-06-03 EP claimed
US-5059606-A COMBINATION OF PYRIMIDINE DERIVATIVES AND CALCIUM ANTAGONISTS TO INDUCE AND STIMULATE HAIR GROWTH AND REDUCE HAIR LOSS L'OREAL (FR) 1991-10-22 US claimed
EP-0319983-A1 Association of pyrimidine derivatives and calcium antagonists to induce and stimulate the hair growth and to reduce hair loss L'OREAL (FR) 1989-06-14 EP claimed
EP-0142756-A2 Methyl-piperazino derivatives with analgesic activity, a process for their preparation, and therapeutic compounds which contain them EURORESEARCH S.R.L. (IT) 1985-05-29 EP claimed