SCHEMBL11518658

SCHEMBL11518658

CC(C)(C)c1cc(Cc2cccc(O)c2Cc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc(C(C)(C)C)c1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.46
HSPA5 P11021 2/20 0.45
CA2 P00918 3/20 0.44
ALDH1A1 P00352 7/20 0.44
TSHR P16473 4/20 0.44
LMNA P02545 2/20 0.44
GAA P10253 2/20 0.44
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
MAPK1 P28482 3/20 0.42
HIF1A Q16665 3/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
BLM P54132 2/20 0.42
ATM Q13315 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
GMNN O75496 1/20 0.42
GABBR2 O75899 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2042110 0.92 DHFR (0.49) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL31245638 0.86 DHFR (0.47) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL292109 0.85 HSPA5 (0.50) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL30464059 0.83 HSPA5 (0.53) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL28384212 0.83 HSPA5 (0.53) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL9817051 0.82 CA2 (0.59) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL28834319 0.81 DHFR (0.41) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL8955910 0.80 HSPA5 (0.51) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL9804719 0.79 ALDH1A1 (0.46) DHFRHSPA5CA2ALDH1A1TSHR
SCHEMBL7710885 0.79 SCN2A (0.49) DHFRHSPA5CA2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4173541-A ANITOXIDANTS CINCINNATI MILACRON CHEMICALS INC. (US) 1979-11-06 US disclosed