Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.47 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219605 | 0.84 | L3MBTL1 (0.49) | KMT2ATSHRHTT | |
| SCHEMBL31448014 | 0.83 | KEAP1 (0.62) | KEAP1EGLN1RAB9AGAAFTO | |
| SCHEMBL1285567 | 0.79 | HPGD (0.62) | KEAP1RAB9AGAACYP2C19KMT2A | |
| SCHEMBL30319510 | 0.79 | HPGD (0.62) | KEAP1RAB9AGAACYP2C19KMT2A | |
| SCHEMBL7738430 | 0.78 | GAA (0.55) | GAAPOLB | |
| SCHEMBL27450922 | 0.78 | KEAP1 (0.66) | KEAP1EGLN1RAB9AGAAFTO | |
| SCHEMBL30289977 | 0.78 | KMT2A (0.65) | KEAP1EGLN1KDM4CAPEX1CYP2C19 | |
| SCHEMBL6844310 | 0.77 | KEAP1 (0.53) | KEAP1EGLN1RAB9AGAAKMT2A | |
| SCHEMBL8116346 | 0.77 | HPGD (0.60) | KEAP1RAB9AGAACYP2C19KMT2A | |
| Salicyluric Acid SCHEMBL570541 | 0.77 | HPGD (0.58) | KEAP1EGLN1RAB9AGAAFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4162319-A | ANTHELMINTICS, PSYCHOTROPIC, CNS, HYPOGLYCOMIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-07-24 | — | — | US | disclosed |
| US-4120961-A | ANTIHELMINTICS, CNS ACITVITY | E. MERCK (DE) | 1978-10-17 | — | — | US | disclosed |
| US-4051243-A | RING SUBSTITUTED PYRAZINO-ISOQUINOLINE DERIVATIVES AND THEIR PREPARATION | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |