Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.45 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11521457 | 0.95 | JAK2 (0.43) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL11524573 | 0.80 | RAB9A (0.46) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL11519411 | 0.80 | RAB9A (0.47) | TYK2JAK2JAK1PPIANPC1 | |
| SCHEMBL11526196 | 0.79 | JAK2 (0.41) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL11522976 | 0.78 | RAB9A (0.45) | TYK2JAK2JAK1PPIANPC1 | |
| SCHEMBL11525516 | 0.77 | PPIA (0.48) | TYK2JAK2JAK1ABL1PPIA | |
| SCHEMBL11604630 | 0.77 | RAB9A (0.48) | TYK2JAK2PPIANPC1RAB9A | |
| SCHEMBL11521949 | 0.77 | ABL1 (0.43) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL11385328 | 0.76 | RAB9A (0.47) | TYK2JAK2JAK1PPIANPC1 | |
| SCHEMBL11521149 | 0.75 | NPC1 (0.46) | TYK2JAK2PPIANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |