Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 8/20 | 0.44 |
| ▸ | JAK2 | O60674 | 6/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11519411 | 0.86 | RAB9A (0.47) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11522976 | 0.84 | RAB9A (0.45) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11519925 | 0.83 | TYK2 (0.46) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11526152 | 0.83 | RAB9A (0.42) | RAB9ANPC1NPSR1TYK2JAK2 | |
| SCHEMBL11522661 | 0.83 | IL2 (0.42) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11520972 | 0.83 | RAB9A (0.45) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11521457 | 0.82 | JAK2 (0.43) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11526321 | 0.81 | STIM1 (0.42) | RAB9ANPC1NPSR1TYK2JAK2 | |
| SCHEMBL11163699 | 0.81 | RAB9A (0.68) | RAB9ANPC1NPSR1MAPTMEN1 | |
| SCHEMBL11523665 | 0.81 | HCRTR1 (0.48) | RAB9ANPC1NPSR1TYK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |