Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 8/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11519411 | 0.86 | RAB9A (0.47) | RAB9ANPC1PPIATYK2JAK2 | |
| SCHEMBL8656115 | 0.84 | RAB9A (0.56) | RAB9ANPC1KDM4EMAPT | |
| SCHEMBL11524573 | 0.84 | RAB9A (0.46) | RAB9ANPC1PPIATYK2JAK2 | |
| SCHEMBL11519534 | 0.83 | RAB9A (0.40) | RAB9ANPC1PPIAHDAC1TYK2 | |
| SCHEMBL11524038 | 0.81 | RAB9A (0.41) | RAB9ANPC1PPIAHDAC1TYK2 | |
| SCHEMBL11163699 | 0.81 | RAB9A (0.68) | RAB9ANPC1MAPT | |
| SCHEMBL11604630 | 0.81 | RAB9A (0.48) | RAB9ANPC1PPIATYK2JAK2 | |
| SCHEMBL11523665 | 0.81 | HCRTR1 (0.48) | RAB9ANPC1TYK2KDM4EMAPT | |
| SCHEMBL11525363 | 0.81 | CHEK1 (0.54) | — | |
| SCHEMBL11519925 | 0.81 | TYK2 (0.46) | RAB9ANPC1PPIAHDAC1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | claimed |
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |