Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10838731 | 0.75 | CYP3A4 (0.59) | CYP3A4CYP2C19CYP2D6KCNH2MEN1 | |
| Hydrochloric Acid SCHEMBL11114957 | 0.74 | CYP3A4 (0.58) | CYP3A4CYP2C19CYP2D6KCNH2MEN1 | |
| SCHEMBL11600408 | 0.72 | CYP3A4 (0.55) | CYP3A4CYP2C19CYP2D6KCNH2CHRM3 | |
| SCHEMBL9397304 | 0.71 | CYP2D6 (0.44) | CYP3A4CYP2C19CYP2D6KCNH2CHRM3 | |
| SCHEMBL11616292 | 0.69 | KCNA3 (0.73) | CYP3A4CYP2C19CYP2D6KCNH2LMNA | |
| Fronepidil SCHEMBL2109579 | 0.69 | CYP3A4 (0.47) | CYP3A4CYP2C19CYP2D6KCNH2LMNA | |
| SCHEMBL9450076 | 0.69 | CYP2D6 (0.45) | CYP3A4CYP2C19CYP2D6KCNH2MEN1 | |
| SCHEMBL11010284 | 0.69 | LMNA (0.46) | CYP3A4CYP2C19CYP2D6KCNH2LMNA | |
| SCHEMBL10675580 | 0.66 | KCNH2 (0.77) | CYP3A4CYP2C19CYP2D6KCNH2LMNA | |
| SCHEMBL11471791 | 0.66 | CCR1 (0.46) | CYP3A4CYP2D6KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130289024-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2013-10-31 | — | — | US | disclosed |
| US-8475804-B2 | Compositions and methods for treatment of filovirus-mediated diseases | U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMAND (US) | 2013-07-02 | — | — | US | disclosed |
| US-20110028564-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | ZALICUS INC. | 2011-02-03 | — | — | US | disclosed |
| US-4999361-A | Cardiovascular disorders, blood vessel relaxants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-03-12 | — | — | US | disclosed |
| EP-0330940-A2 | Trisubstituted amines, process for their preparation and pharmaceutical preparations containing these compounds | Roche Diagnostics GmbH (DE) | 1989-09-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028564-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | FLNA, FLNB, PIGS | CYP3A4 4074/4885CYP2C19 3439/4885CYP2D6 4542/4885 |
| US-20130289024-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | FLNA, FLNB, PIGS | CYP3A4 4074/4885CYP2C19 3439/4885CYP2D6 4542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.