SCHEMBL11524645

SCHEMBL11524645

CC(=O)OCc1cc(COC(C)=O)n(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
IDH1 O75874 1/20 0.39
CYP1A2 P05177 2/20 0.37
CYP2C19 P33261 2/20 0.37
MEN1 O00255 1/20 0.37
CYP2C9 P11712 1/20 0.37
KMT2A Q03164 1/20 0.37
ACSS2 Q9NR19 1/20 0.35
ELANE P08246 1/20 0.35
SLC16A3 O15427 3/20 0.34
SLC16A1 P53985 2/20 0.34
MCTS1 Q9ULC4 2/20 0.34
NPC1 O15118 1/20 0.34
GRM5 P41594 2/20 0.33
MAPT P10636 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPK1 P28482 1/20 0.33
LMNA P02545 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3573464 0.72 SIRT2 (0.49) ALDH1A1CYP1A2CYP2C19MEN1CYP2C9
SCHEMBL3148117 0.71 P2RX7 (0.37) L3MBTL1
SCHEMBL22412880 0.69 MEN1 (0.39) ALDH1A1IDH1CYP1A2CYP2C19MEN1
Alcohol SCHEMBL6432975 0.69 SIRT2 (0.47) ALDH1A1NPC1
SCHEMBL7755231 0.69 SLC16A3 (0.47) ALDH1A1IDH1CYP1A2CYP2C19MEN1
SCHEMBL7713289 0.68 SIRT2 (0.46) ALDH1A1NPC1
SCHEMBL7713293 0.68 ALDH1A1 (0.40) ALDH1A1IDH1CYP1A2CYP2C19MEN1
SCHEMBL1199662 0.68 MAPK1 (0.36) ALDH1A1IDH1CYP1A2CYP2C19MEN1
SCHEMBL16620077 0.68 ALDH1A1 (0.37) ALDH1A1IDH1CYP1A2CYP2C19MEN1
SCHEMBL17084220 0.68 ELANE (0.38) ALDH1A1IDH1CYP1A2CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4157331-A SEDATIVES, TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS HOFFMANN-LA ROCHE INC. (US) 1979-06-05 US disclosed
US-4153799-A ANXIOLYTICS, SEDATIVES, ANTICONVULSANTS, MUSCLE RELAXANTS, PYRAZOLE INTERMEDIATES HOFFMANN-LA ROCHE INC. (US) 1979-05-08 US disclosed
US-4130716-A ANXIOLYTICS, SEDATIVE, MUSCLE RELAXANT, ANTICONVULSANT HOFFMANN-LA ROCHE INC. (US) 1978-12-19 US disclosed