Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11627721 | 1.00 | TSHR (0.30) | TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL11627725 | 1.00 | TSHR (0.30) | TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL11524892 | 1.00 | TSHR (0.30) | TSHRTP53EGLN1EGLN3 | |
| SCHEMBL226972 | 0.84 | — | — | |
| SCHEMBL31412624 | 0.84 | — | — | |
| SCHEMBL28561922 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL3407509 | 0.82 | — | — | |
| Maleic Acid SCHEMBL27995249 | 0.82 | TSHR (0.41) | TSHRTP53EGLN1EGLN3 | |
| Phosphoric Acid SCHEMBL28561912 | 0.81 | — | — | |
| Valine SCHEMBL6439669 | 0.77 | SLC7A5 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4091115-A | ANTIDEPRESSANTS | ROUSSEL UCLAF (FR) | 1978-05-23 | — | — | US | claimed |
| US-4154852-A | ANTIDEPRESSANTS | ROUSSEL UCLAF (FR) | 1979-05-15 | — | — | US | disclosed |
| US-4091115-A | ANTIDEPRESSANTS | ROUSSEL UCLAF (FR) | 1978-05-23 | — | — | US | disclosed |