Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 6/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | TPH1 | P17752 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11521003 | 0.88 | KMO (0.45) | MAPTABL1GHSRNPC1RAB9A | |
| SCHEMBL11521149 | 0.86 | NPC1 (0.46) | MAPTNPC1RAB9AJAK2TYK2 | |
| SCHEMBL11604630 | 0.86 | RAB9A (0.48) | MAPTNPC1RAB9AJAK2TYK2 | |
| SCHEMBL11385328 | 0.85 | RAB9A (0.47) | MAPTNPC1RAB9AJAK2TYK2 | |
| SCHEMBL11522661 | 0.83 | IL2 (0.42) | MAPTNPC1RAB9AJAK2TYK2 | |
| SCHEMBL11519534 | 0.83 | RAB9A (0.40) | MAPTGHSRNPC1RAB9AJAK2 | |
| SCHEMBL11525516 | 0.82 | PPIA (0.48) | MAPTABL1NPC1RAB9AJAK2 | |
| SCHEMBL11524371 | 0.81 | MAPT (0.45) | MAPTGHSRJAK2TYK2 | |
| SCHEMBL11524433 | 0.81 | MEN1 (0.45) | MAPTNPC1 | |
| SCHEMBL11525622 | 0.80 | RAB9A (0.44) | MAPTNPC1RAB9AJAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |