Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.42 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11376439 | 0.90 | RORB (0.51) | MEN1KMT2ASMN1; SMN2MAPTPIK3CD | |
| SCHEMBL11604630 | 0.84 | RAB9A (0.48) | MAPTKDM4ENPC1 | |
| SCHEMBL11521003 | 0.84 | KMO (0.45) | MAPTKMONPC1 | |
| SCHEMBL11521149 | 0.82 | NPC1 (0.46) | MEN1KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL11383754 | 0.82 | GAA (0.46) | MEN1KMT2ANPSR1SMN1; SMN2MAPT | |
| SCHEMBL11385328 | 0.81 | RAB9A (0.47) | MEN1KMT2ANPSR1MAPTNPC1 | |
| SCHEMBL11521954 | 0.81 | TYK2 (0.44) | MEN1KMT2ANPSR1SMN1; SMN2MAPT | |
| SCHEMBL11525622 | 0.81 | RAB9A (0.44) | NPSR1SMN1; SMN2MAPTGAANPC1 | |
| SCHEMBL11525166 | 0.81 | SIRT2 (0.45) | MAPTNPC1 | |
| SCHEMBL11525162 | 0.81 | MEN1 (0.43) | MEN1KMT2ANPSR1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |