Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.35 |
| ▸ | MARS1 | P56192 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11524422 | 0.78 | TRPM5 (0.42) | MEN1KMT2ATRPM5TRPM4 | |
| SCHEMBL7309916 | 0.74 | KMT2A (0.39) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| SCHEMBL7317722 | 0.69 | MEN1 (0.39) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| SCHEMBL6510724 | 0.69 | OPRK1 (0.46) | MEN1KMT2ALMNATRPM5ATM | |
| SCHEMBL11526168 | 0.69 | MARS1 (0.52) | SMN1; SMN2ALDH1A1MARS1 | |
| SCHEMBL9418677 | 0.68 | MARS1 (0.72) | MEN1KMT2ANPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11184701 | 0.67 | EDNRB (0.41) | MEN1KMT2ATRPM5ATMTRPM4 | |
| SCHEMBL27332765 | 0.67 | CYP3A4 (0.54) | LMNA | |
| SCHEMBL7317502 | 0.66 | MEN1 (0.38) | MEN1KMT2ANPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9643919 | 0.66 | MALT1 (0.73) | MEN1KMT2ASMN1; SMN2MALT1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4157331-A | SEDATIVES, TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4153799-A | ANXIOLYTICS, SEDATIVES, ANTICONVULSANTS, MUSCLE RELAXANTS, PYRAZOLE INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4130716-A | ANXIOLYTICS, SEDATIVE, MUSCLE RELAXANT, ANTICONVULSANT | HOFFMANN-LA ROCHE INC. (US) | 1978-12-19 | — | — | US | disclosed |