Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 9/20 | 0.42 |
| ▸ | TRPM4 | Q8TD43 | 4/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11528510 | 0.78 | TRPM4 (0.38) | TRPM5TRPM4NOTUMMEN1KMT2A | |
| SCHEMBL11526484 | 0.78 | MEN1 (0.40) | TRPM5TRPM4MEN1KMT2A | |
| SCHEMBL11526978 | 0.72 | TRPM5 (0.36) | TRPM5TRPM4NOTUMDRD2PTGS2 | |
| SCHEMBL11528229 | 0.68 | OPRK1 (0.53) | PTGS2 | |
| SCHEMBL6510724 | 0.68 | OPRK1 (0.46) | TRPM5TRPM4MEN1KMT2A | |
| SCHEMBL11679438 | 0.65 | PRCP (0.41) | TRPM5TRPM4DRD2DRD1MEN1 | |
| SCHEMBL11184701 | 0.65 | EDNRB (0.41) | TRPM5TRPM4DRD2DRD1MEN1 | |
| SCHEMBL11434769 | 0.65 | EPAS1 (0.38) | TRPM5TRPM4MEN1KMT2A | |
| SCHEMBL11679900 | 0.65 | TRPM5 (0.39) | TRPM5TRPM4DRD2DRD1 | |
| SCHEMBL11526168 | 0.64 | MARS1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4157331-A | SEDATIVES, TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4153799-A | ANXIOLYTICS, SEDATIVES, ANTICONVULSANTS, MUSCLE RELAXANTS, PYRAZOLE INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4130716-A | ANXIOLYTICS, SEDATIVE, MUSCLE RELAXANT, ANTICONVULSANT | HOFFMANN-LA ROCHE INC. (US) | 1978-12-19 | — | — | US | disclosed |