Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.72 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.72 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Menthol SCHEMBL11526858 | 1.00 | TRPM8 (0.72) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL6129363 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL1664660 | 0.87 | TRPM8 (0.81) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL117884 | 0.87 | TRPM8 (0.88) | TRPM8TRPA1EPHX1TRPV1 | |
| Levomenthol SCHEMBL2954662 | 0.87 | TRPM8 (0.88) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL28358153 | 0.87 | TRPM8 (0.68) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL2124686 | 0.86 | TRPM8 (0.78) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL28455572 | 0.85 | TRPM8 (0.84) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL1664554 | 0.85 | TRPM8 (0.84) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL27696394 | 0.85 | TRPM8 (0.84) | TRPM8TRPA1EPHX1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159315-A | DI(2-ETHYLHEXYL) SULFOSUCCINATE SALT, CINNAMON, PEPPERMINT, OR SPEARMINT OIL, CHEWING GUM | GENERAL MILLS, INC. (US) | 1979-06-26 | — | — | US | disclosed |